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KMID : 0370220080520050370
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Yakhak Hoeji
2008 Volume.52 No. 5 p.370 ~ p.375
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Salviae Radix Suppresses Mast Cell-mediated Allergic Response: Inhibition of Src-family Kinase
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Kim Young-Mi
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Abstract
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In this study, the anti-allergic activity and mechanim of Salviae radix (SR) were investigated. The ethanol extract of SR showed significant inhibitory effect on degranulation from antigen-stimulated mast cells and it also inhibited the expression and secretion of TNF-α and IL-4 in antigen-stimulated RBL-2H3 cells. In the mast cell-mediated local animal allergy model, it suppressed the passive cutaneous anaphylaxis in a dose-dependent manner. As its mechanism of action, SR inhibited the activating phosphorylation of Syk, a downstream signaling molecule of Src-family kinase, for the activation of mast cells. The results of the study indicate that the anti-allergic activity of SR is mediated by the inhibition of Src-family kinase in mast cells.
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KEYWORD
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Salviae radix, anti-allergic activity, mast cells, Src-family kinase, Syk kinase
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